Excess use of oxymetazoline can cause rebound congestion which can cause the loss of smell but it do not have any such reported side effect of loss of smell. But alternatively remember, many inflammatory conditions of the nasopharynx can also lead to the loss of smell. The loss of smell is due to nasal inflammation. Hopefully the medications side effects (if indeed caused by afrin (oxymetazoline)) will eventaully resolve, and your sense of taste and smell may come back. There is some evidence that more long term vasoconstriction which Afrin (oxymetazoline) does, can lead to the loss of smell. If this persisits, see an ear nose and throat dr. For an eval. Tell your doctor if any of the following side effects are severe or don’t go away: Dryness in the nose; Burning or stinging feeling in the nose Best wishes. There are now two vaccines currently authorized in the U.S., one developed by Pfizer and BioNTech, another vaccine, developed by Moderna, just received clearance from the Food and Drug Administration and will be distributed in Texas as soon as Monday. There are, however, some side effects that you may want to know about before you start using them. I completely lost the sense of smell and taste after the second dose of Afrin, which was 10 hours apart from the 1st one. A loss of the sense of smell or taste seems to be rare, but it is not always reversible. When I asked my doctor about this side affect he said did not know anything about it and my loss of smell could be from the cold itself. Avoid afrin (oxymetazoline): Avoid afrin (oxymetazoline) and drink plenty of water. One of the most common brands of fluticasone is Flonase nasal spray. The following are some of the side effects that may be associated with oxymetazoline. Any query, please feel free to ask. It is likely to improve when the nasal inflammation subsides. Side effects from fluticasone can depend on the form, dose, and the individual. Find patient medical information for Nasal Spray (oxymetazoline) nasal on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Afrin Sinus (Oxymetazoline) 0.05 % Nasal Spray Side Effects by Likelihood and Severity INFREQUENT side effects If experienced, these tend to have a Severe expression Find everything you need to know about Oxymetazoline Nasal (Afrin), including what it is used for, warnings, reviews, side effects, and interactions. Common Side Effects of Oxymetazoline. Read the side effects of Oxymetazoline as described in the medical literature. So much so that it's not really even commonly mentioned on most adverse effects lists for Afrin (oxymetazoline). Shipments of the COVID-19 vaccine are arriving across the U.S. and you may be wondering what are some common side effects? 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